Great Britain's injury tally has mounted in Moscow as decathlete Ashley Bryant was forced to pull out of the World Championships.
UK Athletics confirmed that the 22-year-old, who had been due to make his senior debut in Moscow, had a hamstring problem.
It is the latest injury blow to strike the British team, which is missing Olympic heptathlon champion Jessica Ennis-Hill because of an Achilles tendon problem.
World 400 metres hurdles champion Dai Greene and Olympic long jump champion Greg Rutherford have also struggled badly for fitness ahead of the championships.
Bryant had already completed three decathlons since May, including a fourth-placed finish at the European Under-23 Championships in Finland.
He said: "Unfortunately I got a grade one hamstring tear last week. I knew I'd be up against it to recover but I thought I had a good chance because it was in good shape in the last few days, so I was hopeful.
"In warm-up today when I had to push it that bit more it wasn't ready for the competition. I'm gutted, but that's sport I guess."
Double Olympic champion Mo Farah was fighting fit as he looked to kick-start the British medal charge in the 10,000m on Saturday night, though.
Organisers will be hoping there are plenty more fans in the Luznhiki Stadium to cheer him on, with a very sparse crowd in for the opening morning of competition, in start contrast to the packed houses of London 2012.
There was more bad news for Britain as Steven Lewis, fifth at London 2012, crashed out in pole vault qualifying.
The 27-year-old was unable to record a height, failing his three attempts at 5.40m.
But Andrew Osagie and Michael Rimmer raised the mood by progressing in the 800m.
Osagie, the Olympic finalist, eased through with plenty to spare, finishing in third place in one minute 46.16 seconds.
Rimmer did not look quite as comfortable in a far quicker heat - indeed the quickest of the lot - but battled his way through the field in the final 200m to also come home third in 1min 45.47secs.
Irish pair Paul Robinson and Mark English both went out.