Arsenal and Holland striker Robin van Persie is a doubt for Wednesday's friendly against England with a groin injury, Oranje coach Bert van Marwijk has confirmed.
Van Persie sat out the last 10 minutes of Holland's hour-long open training session at Wembley after aggravating the problem, which he originally suffered in the Gunners' 5-2 win over Tottenham on Sunday.
The Arsenal frontman, who has been in scintillating form this year, appeared in discomfort towards the end of the training session and missed an eight-a-side practice match at England's national stadium in north London on Tuesday night.
The 28-year-old, who has scored 33 goals for club and country this term, is a doubt for the game at Wembley, although Van Marwijk was optimistic the striker would feature.
"We will have to wait and see but I don't think it's too serious. I am optimistic he will play," Van Marwijk said.
Arsenal were aware Van Persie had picked up an injury, although they released him for international duty as they thought it was only minor.
Despite Van Marwijk's insistence that the injury does not appear serious, the news will surely prove to be a worrying development for Arsene Wenger, who has heavily relied upon the Dutchman this season.
Van Marwijk has been impressed with how prolific Van Persie has been this year for the Gunners.
"Robin is in great form," said the Holland boss, who may now turn to Klaas Jan Huntelaar to lead the line for the visitors if Van Persie is left out. "It's a little bit different this season with Robin. He is scoring a lot of goals now. He is now a centre-forward.
"Normally he is a player who plays in combination, with others. He did that with Cesc Fabregas and Samir Nasri but now he plays very deep as a striker. He has the quality to score goals."