Captain Rio Ferdinand has been ruled out of England's international against Egypt with a back injury.
The Manchester United defender will miss next Wednesday's game at Wembley after feeling a twinge in his back before Tuesday's Barclays Premier League match against West Ham.
That came just three games into his comeback from a long-standing back complaint which kept him out for more than three months.
United boss Sir Alex Ferguson immediately ruled Ferdinand out of Sunday's Carling Cup final and the 31-year-old also misses out on the chance of leading his country into their first game since John Terry was stripped of the captaincy.
"He won't be fit for the England game," said Ferguson. "That is obvious."
Liverpool's Steven Gerrard would appear to be next on the list for Capello, who will be at Chelsea to watch their Premier League encounter with Manchester City - and the meeting between Terry and Wayne Bridge - on Saturday, with either Frank Lampard or Wayne Rooney acting as back-up.
Not that Ferguson is overly interested in Three Lions affairs.
He is more upset at losing Ferdinand to a back injury that has plagued him for 18 months just as Nemanja Vidic was returning to his starting line-up.
"It is a blow for us because I was looking forward to having Ferdinand and Vidic back on Tuesday," reflected the Scot.
"Unfortunately, it wasn't to be. You never know with back injuries and we have been through this before, but we don't think it is too serious. I don't think he will be fit for the AC Milan game but I don't think it will be long afterwards. We think he could be back in two weeks."