Ailing former industry boss Ian Norris has failed at the Supreme Court to avoid extradition to the US where he faces charges of obstructing justice.
Mr Norris, the retired chief executive of Morgan Crucible, won a ruling in 2008 from the then House of Lords that blocked his removal to the US on price-fixing charges.
But the US government pursued him over related charges of obstructing justice and was successful in the lower UK courts.
In November last year Mr Norris appealed against those rulings to the new Supreme Court, arguing that extradition would cause such damage to his and his wife's mental and physical health that it would be incompatible with his right to private and family life under the European Convention on Human Rights.
The Supreme Court on Wednesday unanimously dismissed his appeal.
Lord Phillips, president of the Supreme Court, said: "One has to consider the effect on the public interest in the prevention of crime if any defendant with family ties and dependencies such as those that bind Mr Norris and his wife was thereby rendered immune from extradition to be tried for serious wrong-doing.
"The answer is that the public interest would be seriously damaged.
"It is for this reason that only the gravest effects of interference with family life will be capable of rendering extradition disproportionate to the public interest that it serves.
"This is not such a case."